John Lukens

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John Lukens
Penn Radiation Oncology Perelman - 2nd Floor Office

(215) 316-5151

Fax (215) 349-5445 3400 Civic Center Boulevard Perelman Center for Advanced Medicine Philadelphia, PA 19104

Directions to 3400 Civic Center Boulevard Perelman Center for Advanced Medicine, Philadelphia, PA 19104

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Primary Specialty

Radiation Oncologist

Practice Penn Radiation Oncology Perelman - 2nd Floor
Gender Male
Education University of Pennsylvania School of Medicine
Training Hospital of the University of Pennsylvania
About

John Lukens

I am an Assistant Professor and Site Chief of Head and Neck Cancer in the Department of Radiation Oncology at the University of Pennsylvania. I treat head and neck and skin cancer patients. I work in a multi-disciplinary setting collaborating with head and neck surgeons, Mohs surgeons, and medical oncologists to care for a complex patient population.  

My research interests include de-intensification trials for favorable risk HPV+ oropharyngeal SCC patients, and in this capacity I served as the Principal Investigator of a clinical trial enrolling 150 HPV+ OPSCC patients decreasing both radiation dose and volumes, and correlating outcomes with circulating HPV DNA. 

Another research interest is the integration of immunotherapy into the treatment of metastatic melanoma patients, investigating the use of high dose radiation to salvage responses to melanoma patients not responding to immunotherapy, and correlating with expansion of the T cell receptor repertoire. I now serve as a co-project-leader of a randomized clinical trial investigating dual checkpoint therapy (Ipi/Nivo) +/- hypofractionated RT for patient with metastatic melanoma. 

Services

brachytherapy, external beam radiation therapy, proton beam therapy, radiation treatment for head and neck cancer, reirradiation for recurrent head and neck cancers